Micro- and nanoscale technologies are emerging as powerful enabling tools for tissue engineering and drug discovery. In tissue engineering, micro- and nanotechnologies can be used to fabricate biomimetic scaffolds with increased complexity and vascularization. Furthermore, these technologies can be used to control the cellular microenvironment (i.e., cell cell, cell matrix and cell soluble factor interactions) in a reproducible manner and with high temporal and spatial resolution. In drug discovery, miniaturized platforms based on micro- and nanotechnology can be used to precisely control the fluid flow, enable high-throughput screening, and minimize sample or reagent volumes. In addition, these systems enhance reproducibility and significantly reduce reaction times. This paper reviews the recent developments in the field of micro- and nanoscale technology and gives examples of their tissue engineering and drug discovery applications.
Pharmaceutical companies can’t afford not to adopt real-world evidence as a key part of product development from both a safety and reimbursement perspective. Developing the right approach to conducting late-stage clinical trials will be critical to deciding what types of research to conduct, executing the trials themselves, maximizing your data, and minimizing business risk. Taking a comprehensive view on these trials will allow your company to meet growing evidence demands from payers and providers. ( Author, http://social.eyeforpharma.com)